The Buffalo, Rochester & Pittsburgh Railway ran from central Pennsylvania to the ports of Rochester and Buffalo. It was primarily a coal carrier.

The BR&P Railway took delivery of its first "Mikados" in 1912. These 2-8-2s had 63" drivers and were large enough to handle straight through freight service. The BR&P ordered another 41 Mikados and took delivery of 31 during 1913 and 1914 and the last ten were put on the roster in 1917. ALCO's Brooks Locomotive Works in Dunkirk, New York built the B R&P's 2-8-2s. They were designated Class Z and assigned road numbers 400-447. In January 1931, the B&O took control of the BR&P after which these locomotives were reclassified as Class Q-10 and were given new road numbers 4700-4747.

In January 1, 1932 the Baltimore & Ohio Railroad purchased the BR&P. There are no surviving BR&P 2-8-2 "Mikado" type locomotives.